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This Concept Map, created with IHMC CmapTools, has information related to: 01a. Staphyloccus Aureus, Lots of virulence factors Toxic shock toxin, Most cases are MRSA good drugs Linezolid, Toxic Shock syndrome -Toxic Shock toxins = super antigens -Only affects people w/out antibodies to TST (% pop) includes Menstrual toxic shock -Problem with super absorbant tampons, Impetigo -Identical to Strep pyogenes see also Bacterial skin infections (MuscSkelInt), STAPHYLOCOCCUS AUREUS Coagulase+, Catalase+, Lots of toxins, SSSS, Impetigo, Common, extracellular Ref: Pages 1026-1031; Microcard 12, 13 Skin Infection bug Coagulase+ -Other staph sp are not coag+, STAPHYLOCOCCUS AUREUS Coagulase+, Catalase+, Lots of toxins, SSSS, Impetigo, Common, extracellular Ref: Pages 1026-1031; Microcard 12, 13 Skin Infection bug Biofilm producer, STAPHYLOCOCCUS AUREUS Coagulase+, Catalase+, Lots of toxins, SSSS, Impetigo, Common, extracellular Ref: Pages 1026-1031; Microcard 12, 13 Skin Infection prevention WASH HANDS!, STAPHYLOCOCCUS AUREUS Coagulase+, Catalase+, Lots of toxins, SSSS, Impetigo, Common, extracellular Ref: Pages 1026-1031; Microcard 12, 13 Skin Infection presentations Community acquired MRSA -Often assoc w/ Panton Valentine -More severe skin infx, often with necrotizing pneumonia, Catalase + -Protection against H202 -All Staphy sp are cat+ unlike Coagulase+ -Other staph sp are not coag+, STAPHYLOCOCCUS AUREUS Coagulase+, Catalase+, Lots of toxins, SSSS, Impetigo, Common, extracellular Ref: Pages 1026-1031; Microcard 12, 13 Skin Infection presentations Post surgical wound, STAPHYLOCOCCUS AUREUS Coagulase+, Catalase+, Lots of toxins, SSSS, Impetigo, Common, extracellular Ref: Pages 1026-1031; Microcard 12, 13 Skin Infection presentations Endocarditis -Aortic insufficiency, STAPHYLOCOCCUS AUREUS Coagulase+, Catalase+, Lots of toxins, SSSS, Impetigo, Common, extracellular Ref: Pages 1026-1031; Microcard 12, 13 Skin Infection bug Can hid out in non-prof. phagocytes, STAPHYLOCOCCUS AUREUS Coagulase+, Catalase+, Lots of toxins, SSSS, Impetigo, Common, extracellular Ref: Pages 1026-1031; Microcard 12, 13 Skin Infection presentations Local infections with diffuse skin rash, STAPHYLOCOCCUS AUREUS Coagulase+, Catalase+, Lots of toxins, SSSS, Impetigo, Common, extracellular Ref: Pages 1026-1031; Microcard 12, 13 Skin Infection bug MSCRAMMS - Attachment protein -Fironectin -Fibrinogen -Elastin -Collagen, Spread by nose to hand contact Infx following damage to skin/membranes, Lots of virulence factors Peptidoglycna, teichoic acid -Trigger inflammation, Most cases are MRSA good drugs Vanco (resistance very rare) (IV Only), Toxic Shock syndrome -Toxic Shock toxins = super antigens -Only affects people w/out antibodies to TST (% pop) more common than Menstrual toxic shock -Problem with super absorbant tampons, STAPHYLOCOCCUS AUREUS Coagulase+, Catalase+, Lots of toxins, SSSS, Impetigo, Common, extracellular Ref: Pages 1026-1031; Microcard 12, 13 Skin Infection epidemiology Most common cause of bacteremia, Local infections with diffuse skin rash Staph Scalded Skin Syndrome (SSSS) -Not an inflammatory process -Proteases break up desmosomes -Diffuse scalding = Ritter's Disease -No long term effects -More common in babies